Lipid Evolution

Anti-inflammatory - Anti-aging Lipid Pharmaceuticals

Lipid Evolution Ltd. is a new research development and manufacturing company with a specific focus on lipids known as Specialized Pro-resolving Mediators (SPMs)1,2 These unique endogenous molecules, derived from EFA precursors, possess highly potent anti-inflammatory activity and function via pro-resolution mechanisms that are fundamentally different to those of existing anti-inflammatories such as NSAIDs and steroids.3 These specific mechanisms dilineate the SPMs as anti-ageing agents relating to the now rapidly evolving field of Inflamm-aging.4,5 In this context it is highly significant that circulatory SPM levels are observed to significantly decrease with age in humans.6 Sub-optimal levels of the SPMs or compromised responsiveness to them leads to inflammaging which underpins major age related diseases.6

Native SPM are short lived transient molecules and therefore equipotent metabolically stabilized mimetics are being developed.7 These compounds have great potential for translation into therapeutics not only to combat ageing associated inflammatory pathologies1,2,3 such as neurodegenerative disease, cancer, cardiovascular disease, obesity, inflammatory bowel disease, rheumatoid arthritis and kidney disease and many other inflammatory conditions but also as potential Longevity Therapeutics to prolong healthy life span.4,5,6

References:

  1. C. N. Serhan. Treating inflammation and infection in the 21st century. The FASEB Journal 2018 vol 33, No.4 pp1273-1288
  2. M.C. Basil, B.D. Levy, Specialized pro-resolving mediators: endogenous regulators of infection and inflammation, Nat. Rev. Immunol. 2016, 16 (1) 51–67.
  3. G. L. Bannenberg. Therapeutic applicability of anti-inflammatory & proresolving PUFA – derived lipid mediators. The Scientific World Journal 2010, 10, pp.676-712
  4. R. Doyle et.al. Pro-resolving lipid mediators: Agents of ant-ageing. Seminars in Immunology 2018, 40, pp36-48
  5. J. M. Rea et. al. Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines. Frontiers in Immunology 2018, doi: 10.3389/fimmu.2018.00586
  6. S.Gangemi et.al. Aging is characterized by a profound reduction in anti- inflammatory lipoxin A4 levels. Exp. Gerontol. 2005 40(7):612-4.
  7. Y-P Sun et.al. Ant-inflammatory and pro-resolving properties of benzo-lipoxin A4 analogs. Prostaglandins Leukot. Essent. Fatty Acids 2009 81(5-6) pp 356-66


LipidEv - Synthesis development, production and supply of SPMs

Information on LipidEv's development projects and SPM analog products will be announced via the website in the near future.